Netilmicin (NTM) is one of the first-line drugs for lower respiratory tract infections (LRTI)\ntherapy, but its nephrotoxicity and ototoxicity caused by intravenous injection restrict its clinical\napplication. Dry powder inhalation (DPI) is a popular local drug delivery system that is introduced\nas a solution. Due to the nature of NTM hygroscopicity that hinders its direct use through DPI, in this\nstudy, L-leucine (LL) was added into NTM dry powder to reduce its moisture absorption rate and\nimprove its aerosolization performance. NTM DPIs were prepared using spray-drying with different\nLL proportions. The particle size, density, morphology, crystallinity, water content, hygroscopicity,\nantibacterial activity, in vitro aerosolization performance, and stability of each formulation were\ncharacterized. NTM DPIs were suitable for inhalation and amorphous with a corrugated surface.\nThe analysis indicated that the water content and hygroscopicity were decreased with the addition\nof LL, whilst the antibacterial activity of NTM was maintained. The optimal formulation..............
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